Periods/week : 3 Periods & 1 Tut /week. Ses. : 30 Exam : 70 Examination (Practical): 3hrs. Credits: 4
Definitions, Sequencing, Biological sequence/structure, Genome Projects, Pattern recognition an prediction, Folding problem, Sequence Analysis, Homology and Analogy.
2. Protein Information Resources
Biological databases, Primary sequence databases, Protein Sequence databases, Secondary databases, Protein pattern databases, and Structure classification databases.
3. Genome Information Resources
DNA sequence databases, specialized genomic resources
4. DNA Sequence analysis
Importance of DNA analysis, Gene structure and DNA sequences, Features of DNA sequence analysis, EST (Expressed Sequence Tag) searches, Gene hunting, Profile of a cell, EST analysis, Effects of EST data on DNA databases
5. Pair wise alignment techniques
Database searching, Alphabets and complexity, Algorithm and programs, Comparing two sequences, sub-sequences, Identity and similarity, The Dotplot, Local and global similarity, different alignment techniques, Dynamic Programming, Pair wise database searching.
6. Multiple sequence alignment
Definition and Goal, The consensus, computational complexity, Manual methods, Simultaneous methods, Progressive methods, Databases of Multiple alignments and searching
7. Secondary database searching
Importance and need of secondary database searches, secondary database structure and building a sequence search protocol
8. Analysis packages
Analysis package structure, commercial databases, commercial software, comprehensive packages, packages specializing in DNA analysis, Intranet Packages, Internet Packages.
1. Introduction to Bioinformatics, T K Attwood & D J Parry-Smith
Addison Wesley Longman
2. Bioinformatics- A Beginner’s Guide, Jean-Michel Claveriw, Cerdric Notredame
WILEY dreamlech India Pvt. Ltd
1. Introduction to Bioinformatics, Arthur M.Lesk, OXFORD publishers (Indian Edition)